Cost-effectiveness analysis of abiraterone, docetaxel or placebo plus androgen deprivation therapy for hormone-sensitive advanced prostate cancer

Cost-effectiveness analysis of abiraterone, docetaxel or placebo plus androgen deprivation therapy for hormone-sensitive advanced prostate cancer

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ABSTRACT Objective To evaluate the cost-effectiveness of the addition of chemotherapy or abiraterone to here androgen deprivation.Methods We developed an analytical model to determine the cost-effectiveness of the addition of docetaxel or abiraterone versus androgen deprivation therapy alone.Direct and indirect costs were included in the model.

The effects were expressed in Quality-Adjusted Life Years adjusted for side effects.Results Compared to androgen deprivation therapy alone, the addition of chemotherapy and of abiraterone generated 0.492 and 0.

999, respectively, in Quality-Adjusted Life Years.Abiraterone led to iphone 13 price dallas a Quality-Adjusted Life Years gain of 0.506 compared to docetaxel.

The incremental costs per Quality-Adjusted Life Years were R$ 133.649,22 for docetaxel, R$ 330.828,70 for abiraterone and R$ 571.

379,42 for abiraterone compared to docetaxel, respectively.Conclusion The addition of chemotherapy to androgen deprivation therapy is more cost-effective than the addition of abiraterone to androgen deprivation therapy.However, discounts on abiraterone cost might improve cost-effectiveness.